Doxycycline stops the growth of bacteria by allosterically binding to the 30Sprokaryotic ribosomal unit during protein synthesis.
Doxycycline is active against Gram-positive and Gram-negative bacteria. Doxycycline acts by blocking the union between aminoacyl-tRNA (transfer RNA) to the mRNA-ribosome complex, interfering with protein synthesis.
In veterinary medicine, MEDOX 20% is typically administered orally to cattle, pigs, and poultry. It is effective against respiratory and gastrointestinal infections caused by micro-organisms sensitive to doxycycline, like E. coli, Salmonella, Mycoplasma, Pasteurella, Bordetella, Streptococcus, Campylobacter and Haemophilus spp. in calves, poultry and pigs.
Each 1 ml contains:
Doxycycline 200 mg
For oral administration via drinking water.
Poultry: 250-600 ml per 1,000 litres of drinking water during 3-5 days.
Calves: 2.5 ml per 50 kg bodyweight during 3-5 days.
Pigs: 5 ml per 100 kg bodyweight or 500-800 ml per 1,000 litres of drinking water during 3-5 days.
Medicated drinking water should be used within 24 hours.
Note: for pre-ruminant calves and lambs only.